Another Calcium Paradox?
نویسندگان
چکیده
منابع مشابه
Another calcium paradox?
In a number of important diseases, the clinical course is defined principally by the host response, more so than by the initiating environmental insult. Clinicians rely on identification of this host response for diagnosis and may select those responses as targets for therapeutic intervention. Atherosclerosis is one such disease. The clinical course was once felt to result from progressive accu...
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We show that a single binomial observation carries absolutely no evidential value for discriminating the null hypothesis θ = 1/2 from a broad class of alternative hypotheses that allow θ to be between 0 and 1. In contrast, interval estimation methods suggest that a single binomial observation does provide some evidence against the null hypothesis. The resolution of this paradox requires the ins...
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21 See article by Ban et al. [3] (pages 556 –567) in this [3] address two hypotheses. The first is that Ca overload 21 issue. causes futile energy-dissipating mitochondrial Ca cy21 cling. This cycling involves mitochondrial Ca uptake 21 21 In the calcium paradox, Ca -free incubation produces through the mitochondrial Ca uniporter driven by the 1 1 Na loading of cardiac myocytes largely mediated...
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Much of the present knowledge of the heart’s physithat the electronmicroscopic changes in ‘‘stone heart’’ (a ology is derived from experiments with isolated perfused dreaded and lethal complication of heart surgery) was hearts. Usually based on the technique of Langendorff. It identical to the changes observed in the calcium paradox. was, and largely still is, a logic defying problem that the W...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2001
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvb.21.10.1561